As Dr. Muto, players forge through 22 vast levels on four distinct planet scapes: from the junkyard world of Totltec, to the half-drowned water world of Aquem, through the smog-choked skies of Flotos, and finally, to the forbidden mines of Mazon. Armed with his newest invention, the Splizz-gun, Dr. Muto morphs into a variety of DNA-spliced-up creatures including an alien spider, miniature mouse, and hulking gorilla. By morphing, Dr. Muto gains each creature's abilities and physical attributes--such as the ability to cling to webs, squeeze into tight spaces, or breathe underwater--all to better crush, outwit, and outlast ten different enemies.